New strategies for structure-guided design of AIDS antivirals
نویسندگان
چکیده
منابع مشابه
DESIGN AND STRUCTURE OF A NEW DEVICE FOR AUDITORY ELECTRICAL STIMULATION FOR SUPPRESSION OF TINNITUS
Auditory Electrical Stimulation for Tinnitus Suppression Tinnitus is the conscious experience of sound which arises in the head of its owner, but without a voluntary origin obvious to that person. About 10-15% of all adults report prolonged spontaneous tinnitus (PST). There are a lot of methods for suppressing this complaint. One of these methods is electrical stimulation. Electrical stimu...
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deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...
Antivirals and antiviral strategies.
In recent years, the demand for new antiviral strategies has increased markedly. There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral infections such as HIV and hepatitis B and C, and the emergence of new viruses such as the SARS coronavirus. The potential danger of haemorrhagic fever viruses and eradicated viruses such as vario...
متن کاملStructure-Guided Design Affirms Inhibitors of Hepatitis C Virus p7 as a Viable Class of Antivirals Targeting Virion Release
UNLABELLED Current interferon-based therapy for hepatitis C virus (HCV) infection is inadequate, prompting a shift toward combinations of direct-acting antivirals (DAA) with the first protease-targeted drugs licensed in 2012. Many compounds are in the pipeline yet primarily target only three viral proteins, namely, NS3/4A protease, NS5B polymerase, and NS5A. With concerns growing over resistanc...
متن کاملStrategies for AIDS vaccines.
In the global AIDS epidemic, over half of all infections have occurred in people less than 25 years old resulting in profound social, economic and demographic consequences. Current estimates indicate that the present 15 million HIV infections will increase to over 30 million by the end of the millennium. For most countries a safe and effective vaccine offers the only hope of controlling the spr...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2005
ISSN: 0079-6107
DOI: 10.1016/j.pbiomolbio.2004.07.004